NMR-based metabonomic analyses of horse serum: detection of metabolic markers of disease
S. L. Ralston, L. Pappalardo, I. Pelczer, and P. F. Spears
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NMR-based Metabonomic Analysis of Serum From Standardbred
Yearlings With or Without Hock Osteochondrosis Dessicans Lesions:
Preliminary Study
| Metabonomic analyses
use multivariate statistical cluster analyses of Nuclear Magnetic
Resonance (NMR) spectra from biological samples to find metabolic
markers associated with diseases^{1-4^}. The detection of significant
differences in large numbers of metabolites from diseased and normal
individuals can lead to the development of novel diagnostic and
therapeutic modalities based on deeper understanding of the metabolic
processes involved^{1-4^}. Osteochondrosis dessicans (OCD) is a
developmental orthopedic disease that has been well documented to have
a genetic basis in Standardbreds and other breeds ^{as quoted in 5}^
but the actual metabolic defects causing the lesions have not been well
defined^{5}^. The presence of OCD lesions has been correlated with
abnormal insulin sensitivity in young horses but never proven to be a
true causal factor^{6, 7}^.
Our overall objective was to determine if metabonomic analyses of NMR
spectra of serum samples of yearling horses would detect consistent
metabolic differences between yearlings that had had hock OCD versus
closely related yearling raised in the same environment that did not
have hock lesions. |
Equine Science Center
Rutgers University
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